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KMID : 0363220070450070687
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Korean Journal of Dermatology
2007 Volume.45 No. 7 p.687 ~ p.691
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A Case of CD30 Positive ALK-Negative Systemic Anaplastic Large Cell Lymphoma Involving Bone Marrow
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Lee Yong-Hwan
Suh Moo-Kyu
Kim Soo-Ho
Jang Suk-Yong
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Abstract
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CD 30 positive anaplastic large cell lymphoma (ALCL) is a type of non-Hodgkin’s lymphoma, a tumor that is composed of mostly mast cells expressing CD30 antigens. According to the 2005 World Health Organization-European Organization for Research and Treatment of Cancer (WHO-EORTC) classification, it can be classified as systemic ALCL and primary cutaneous CD30 positive T-cell lymphoproliferative disorder. Systemic ALCL can be subclassified into ALK positive and negative. There have been many cases of primary cutaneous CD30 positive T-cell lymphoproliferative disorder, but reports of systemic ALCL have been rare. We report a case of CD30 positive/ALK negative systemic anaplastic large cell lymphoma involving bone marrow in a 51 year-old-male who showed two pruritic, 1.51.00.8 cm and 1.00.50.4 cm sized, erosive, erythematous nodules on the right thigh and calf.
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KEYWORD
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Anaplastic large cell lymphoma, Bone marrow involvement
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